In specific, doctor enzymes involved in cellmembrane peptidoglycan biosynthesis, Mur F and Mur E, dihydrofolate reductase and doctor penicillin binding proteins PBP1band PBP3 were used. The acquired effects failed clinical explain doctor antibacterial endeavor, while according scientific docking evaluation, theantifungal endeavor can be explained by doctor inhibition of doctor CYP51 enzyme for many of doctor compounds while antibacterialactivity may depends on distinct elements . The next paper refers clinical inhibitors of protein tyrosine phosphatase PTP1B as a target for type II diabetes mellitus. PTP1Bis currently regarded as one of doctor best tested biological targets for non insulin dependent diabetic and obese americans. Several small molecule PTP1B inhibitors discussed as diaminopyrroloquinazoline, triazines, pyrimido triazine derivatives,2 benzylamino 1 phenylethanols, ureas, acetamides and piperazinylpropanols, phenylsulphonamides and phenylcarboxamides,benzamido, arylcarboxylic acid derivatives, arylsufonyl derivatives, thiazoles, isothiazolidiones and thiazolodinonesare regarded as promising drug candidates which could be derivatized for doctor technology of huge selection of combinatorialmolecules. Inhibitors containing doctor sulfonyl moiety, viz.